- Each 5 ml Contains:
- Levocetrizine Hydrochloride IP 2.5 mg 5 mg
- Montelukast Sodium IP eq. to Montelukast 4 mg
- 60 ml
- Rs 103
Levocetirizine is the selective H1 recptor antagonist that blocks the histamine receptor present on the surface of the mast cells. Levocetirizine provides better efficacy then cetirizine because levocetirizine has greater affinity for H1 receptors than cetirizine. Montelukast is a member of the leukotriene receptor antagonist (LTRA) category of drugs. Montelukast is used in adjunct therapy along with inhaled corticosteroids or other agents in asthma step therapy.
- Perennial allergic rhinitis
- Chronic idiopathic urticarial
- Exercise-Induced Bronchospasm
Mechanism of action
Levocetirizine selectively inhibits the H1 receptor and prevents the release of histamine which causes smooth muscle contraction, increase vascular permeability, stimulation of cough. All this acitivities is blocked by levocetirizine.
Montelukast is a leukotriene receptor antagonist that demonstrates a marked affinity and selectivity to the cysteinyl leukotriene receptor type-1 in preference to many other crucial airway receptors like the prostanoid, cholinergic, or beta-adrenergic receptors. Leukotrienes are eicosanoids released by a variety of cells like mast cells and eosinophils. They bind to corresponding CysLT receptors located on respiratory airway smooth muscle cells, airway macrophages, and on various pro-inflammatory cells like eosinophils and some specific myeloid stem cells activities that facilitate the pathophysiology of asthma and allergic rhinitis are stimulated.
Levocetirizine is well orally absorbed and is highly bound to plasma proteins. It is poorly metabolized, but undergoes O-dealkylation and glucuronide conjugation. The half-life of levocetrizine is 8-9 hours.
Montelukast is quickly absorbed from GIT with the bioavailability of 64%. The average volume of distribution of montelukast is 8-11 L with protein binding exceeding 99%. It is majorly metabolised by CYP enzyme family and is excreted into bile and feces with a half-life of 2.7-5.5 hours.
The product is generally considered safe when taken in recommended doses however common side effects include:
- Upset stomach
- Skin Rash
Not to be used in the following conditions:
- Renal impairment Depression Inflammation of blood vessels in the skin Renal impairment Narrow angle glaucoma