Overview

This combination is very effective to provide relief against fever and pain.

Indications

• Used in rheumatoid arthritis
• Used osteoarthritis
• Headache
• Muscle pain
• Backache
• Toothaches
• Cold and fever

About Composition

Diclofenac:
Diclofenac is phenylacetic acid derivative and non -steroidal anti -inflammatory drug Diclofenac inhibit cox -1 and cox-2 enzyme and prevents the synthesis of prostaglandins.

Paracetamol:
Paracetamol is known as acitominophen which is a pain releiver and fever reducer.

Mechanism of Action

Diclofenac inhibits the synthesis of prostaglandins by inhibiting the cox-1 and cox-2 enzyme and prevents the formation of PGG2 which the precursor for the synthesis of other prostaglndines.
Paracetamol is a weak inhibition of COX-1 and COX-2, further inhibiting prostaglandin synthesis.

Pharmacokinetics

Absorption: Both the drugs are orally absorbed from the GIT.
Protein Binding: Diclofenac is mainly bound to albumin whereas paracetamol do not show protein binding.
Metabolism: Diclofenac undergoes oxidation and conjugation.
Excretion: Both are excreted via urine.

Side Effects

• Yellowing of skin and eyes.
• Nausea
• Vomiting
• Dark urine
• Constipation
• Gas
• Heartburn
• Dizziness

Contraindication

• Contraindicated in third trimester of pregnancy
• Contraindicated in hypersensitivity.
• In gastrointestinal bleeding.
• Contraindicated in acute liver failure.