THYCORIL-4-ACP Tablets

Composition
  • Each film coated tablet contains:
  • Thiocolchicoside 4 mg
  • Aceclofenac 100 mg
  • Paracetamol 325 mg
Packing
  • 10x1x10

MRP
  • 223

Overview

Aceclofenac Paracetamol Thiocolchicoside tablets is used in lower backache pain associated with muscle spasm,spondylitis and lumbago,Frozen shoulder,sports injury and trauma.

Indications

  • Strains and sprains
  • Frozen shoulder
  • Spondylitis and Lumbago
  • Sports injury and trauma

About Composition

Aceclofenac is an orally administered phenylacetic acid derivative with effects on a variety of inflammatory mediators. It is from the class of non-steroidal anti-inflammatory drug (NSAID), related to diclofenac. Through its analgesic and anti-inflammatory properties, aceclofenac provides symptomatic relief in a variety of painful conditions.

Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside with a relaxant effect on skeletal muscle, has been found to displace both [3H]gamma-amino butyric acid ([3H]GABA) and [3H]strychnine binding, suggesting an interaction with both GABA and strychnine-sensitive glycine receptors.



Paracetamol or Acetaminophen belongs to a group of medicines known as non-opiate, analgesic and antipyretic, or painkillers. It is used to relieve mild-to-moderate pain. It is also useful for lowering a raised temperature (fever).
Acetaminophen is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.

Mechanism of action

Aceclofenac is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. It increases glycosaminoglycans (GAG) synthesis, the principal macromolecule of the extracellular matrix, which aids in repair and regeneration of articular cartilage. Thus, aceclofenac has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre. Absorption: Aceclofenac: Rapidly absorbed; almost 100% bioavailability; peak plasma levels reached about 1.25-3 hr after oral admin. Distribution: Aceclofenac: >99.7% bound to plasma proteins; distributes into synovial fluid. Paracetamol: Distributes throughout most fluids of the body. Metabolism: Aceclofenac: Probably metabolised by CYP2C9; average plasma elimination half-life: 4-4.3 hr. Paracetamol: Mainly metabolised hepatically; plasma elimination half-life: 1-4 hr. Excretion: Aceclofenac: About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites. Paracetamol: Most metabolites are removed in the urine within 24 hr.

Pharmacokinetics

It is absorbed orally but its absorption decreases with food Oral bioavailability of thyroxine is 75%

Side Effects

  • Nausea
  • allergic reactions
  • Diarrhoea
  • Headache
  • Drowsiness
  • Insomnia
  • Fever

Contraindication

Hypersensitivity. Moderate to severe renal or hepatic impairment; severe heart failure; pregnancy (third trimester).