DYCOTIF-PLUS Tablets

Composition
  • Each Tablet Contain:
  • Diclofenac 50 mg, Paracetamol 325 mg
Packing
  • 10x2x10
    (Blister)
MRP
  • 30.80

Overview

This combination is very effective to provide relief against fever and pain.

Indications

  • Used in rheumatoid arthritis
  • Used osteoarthritis
  • Headache
  • Muscle pain
  • Backache
  • Toothaches
  • Cold and fever

About Composition

Diclofenac:
Diclofenac is phenylacetic acid derivative and non -steroidal anti -inflammatory drug Diclofenac inhibit cox -1 and cox-2 enzyme and prevents the synthesis of prostaglandins.

Paracetamol:
Paracetamol is known as acitominophen which is a pain releiver and fever reducer.

Mechanism of Action

Diclofenac inhibits the synthesis of prostaglandins by inhibiting the cox-1 and cox-2 enzyme and prevents the formation of PGG2 which the precursor for the synthesis of other prostaglndines.
Paracetamol is a weak inhibition of COX-1 and COX-2, further inhibiting prostaglandin synthesis.

Pharmacokinetics

Absorption: Both the drugs are orally absorbed from the GIT.
Protein Binding: Diclofenac is mainly bound to albumin whereas paracetamol do not show protein binding.
Metabolism: Diclofenac undergoes oxidation and conjugation.
Excretion: Both are excreted via urine.

Side Effects

  • Yellowing of skin and eyes.
  • Nausea
  • Vomiting
  • Dark urine
  • Constipation
  • Gas
  • Heartburn
  • Dizziness

Contraindication

  • Contraindicated in third trimester of pregnancy
  • Contraindicated in hypersensitivity.
  • In gastrointestinal bleeding.
  • Contraindicated in acute liver failure.